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REMERGE

Regenerative Medicine Research Group

REMERGE Members

Fionnuala Lundy, Chair of REMERGE

Reader

Fionnuala's research focuses on the interplay between the innate immune response to infection, and the differentiation and regenerative potential of stem cells. Her work on pain and neurogenic inflammation, and the neuro-inflammatory response to infection, extends into the related field of transient receptor potential (TRP) channel research and the modulation of these important channels during the inflammatory and regenerative processes. Fionnuala is interested in developing non-animal models of disease to study the roles of neuro-inflammatory factors in TRP channel function. To this end she has developed models of human sensory nerves differentiated from human dental pulp stem cells (hDPSCs) and induced pluripotent stem cells (iPSCs).

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Ikhlas El Karim

Senior Lecturer and Consultant in Restorative Dentistry

My research aim is to develop minimally invasive, biologically based regenerative therapies for dental disease. We are particularly interested in: 1. Exploring potential mechanisms and strategies for optimal differentiation of dental stem cells with particular focus on the impact of inflammation on their regenerative potential 2. Developing in-vitro and in-vivo models to study neuronal-immune cells signalling in inflammation and pain 3. Regenerative endodontics and minimal intervention clinical studies

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Denise Fitzgerald

Professor of Neuroimmunology

Our group focuses on Regenerative Neuroimmunology with a particular interest in Multiple Sclerosis and other demyelinating, inflammatory and degenerative diseases of the CNS. We are investigating how immune cells, particularly T cells, influence myelin regeneration in the CNS.

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Danny McAuley

Professor of Intensive Care Medicine

Research Interests: Cell therapy trials in the critically ill

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Professor Danny McAuley

Cecila O'Kane

Clinical Professor

Research interests: MSCs in critical care and pulmonary NTM infection

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Dr Cecilia O'Kane

Andriana Margariti

Senior Lecturer

Research interests: stem cells, cell reprogramming, vascular diseases, diabetes, endothelial cell dysfunction

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Dr Andriana Margariti

Rebecca Ingram

Senior Lecturer

Research interests: the role of the lymphocytes in the inflammatory and repairatory process.

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Susan Clarke

Senior Lecturer, School of Nursing and Midwifery

My research is centred on promoting bone regeneration and in developing novel biomaterials with osteoinductive capabilities for tissue engineering applications. My current research projects include: investigating novel bioactives from marine organisms for osteogenic activity; controlling the resorption of orthopaedic implants; delivering novel therapeutics in orthopaedic implants; investigating predictors of the adult progenitor/stem cell reserve.

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Christina Branco

Lecturer, Centre for Cancer Research and Cell Biology

I am interested in organ-specific physiological and metabolic properties of endothelial cells, local regulation of blood flow and impact on organ function. My group has specifically focused on the effect of endothelial cell behaviour in metastatic cancer, and the role of hypoxia and HIF in the reprogramming of endothelial cell responses.

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Hong Guo-Parke

Postdoctoral Research Fellow

Research interests: Host-pathogen interactions in chronic lung inflammation

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Eric "Rick" Campbell

Lecturer, The Wellcome-Wolfson Institute for Experimental Medicine

Research interests: Inflammatory Bowel Disease, resolution of inflammation, mucosal wound healing, gut-microbial homeostasis, stem cell fate determination.

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David Grieve

Professor of Cardiovascular Physiology

My research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of oxidative stress, novel peptide hormones, endothelial progenitor cells, and the influence of diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and tissue culture, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for potential therapeutic benefit.

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Neil Heron

Clinical Lecturer, Centre for Public Health

Research interests: sport medicine, musculoskeletal, injection therapies, physical activity

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